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ea0029p1199 | Obesity | ICEECE2012

Time-course of changes of GLUT4 expression in insulin-sensitive tissues in an animal model of metabolic syndrome

Lehnen A. , Leguisamo N. , Borges J. , Machado U. , Okamoto M. , Markoski M. , Pinto G. , Meurer L. , Schaan B.

Background: Reduced GLUT4 expression in insulin-sensitive tissues, insulin resistance, inflammation, nonalcoholic steatohepatitis (NASH) and hypertension are pathophysiologic changes expected in metabolic syndrome animal models.Aims: To fully characterize the development and maintenance of metabolic syndrome features over time (GLUT4 in insulin-sensitive tissues, insulin resistance, inflammation, blood pressure and liver changes) in spontaneously hyperte...

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ea0029p299 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Short-term detraining cannot reverse insulin sensitivity improvement and serum retinol binding protein 4 in spontaneously hypertensive rats previously submitted to aerobic exercise

Lehnen A. , Pinto G. , Borges J. , Markoski M. , Schaan B.

Background: Elevated serum retinol binding protein 4 (RBP4) levels were previously described in insulin-resistance states. Recently it was shown that RBP4 contributes, at least partly, to the pathogenesis of insulin resistance in spontaneously hypertensive rats (SHR), but the effects of exercise training and time-course of changes after detraining on RBP4 levels have not yet been explored.Aims: To examine the effects of exercise training and short-term d...

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Endocrine Abstracts

Time-course of changes of GLUT4 expression in insulin-sensitive tissues in an animal model of metabolic syndrome

Short-term detraining cannot reverse insulin sensitivity improvement and serum retinol binding protein 4 in spontaneously hypertensive rats previously submitted to aerobic exercise

BiosciAbstracts